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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRS4
All Species:
3.33
Human Site:
S517
Identified Species:
10.48
UniProt:
O14654
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14654
NP_003595.1
1257
133768
S517
Q
G
S
S
S
H
S
S
G
G
N
Q
C
S
G
Chimpanzee
Pan troglodytes
XP_001134895
1241
131474
G499
H
R
C
T
P
G
T
G
L
G
T
S
P
A
L
Rhesus Macaque
Macaca mulatta
XP_001092171
1113
119935
G445
S
G
G
G
K
N
S
G
G
G
K
G
S
G
S
Dog
Lupus familis
XP_549179
1343
142162
S521
S
S
G
G
N
Q
C
S
G
G
G
Q
G
S
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0Y7
1216
130128
G511
G
S
S
S
Q
G
S
G
G
R
Q
G
S
G
G
Rat
Rattus norvegicus
P35570
1235
131160
T494
H
R
Y
I
P
G
A
T
M
G
T
S
P
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026741
1240
131795
A487
H
Y
I
L
S
R
G
A
N
G
H
R
C
T
P
Frog
Xenopus laevis
Q9DF49
1074
117892
Q405
A
P
F
N
S
G
Y
Q
S
R
S
A
S
L
P
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
25.1
83.9
78.2
N.A.
76.2
25.2
N.A.
N.A.
21.5
29.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
39.1
85.1
82.4
N.A.
81.6
39.8
N.A.
N.A.
36.2
42.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
26.6
40
N.A.
33.3
6.6
N.A.
N.A.
20
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
33.3
46.6
N.A.
33.3
26.6
N.A.
N.A.
46.6
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
0
0
0
0
13
13
0
0
0
13
0
25
0
% A
% Cys:
0
0
13
0
0
0
13
0
0
0
0
0
25
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
13
25
25
25
0
50
13
38
50
75
13
25
13
25
38
% G
% His:
38
0
0
0
0
13
0
0
0
0
13
0
0
0
0
% H
% Ile:
0
0
13
13
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
13
0
0
0
0
0
13
0
0
0
0
% K
% Leu:
0
0
0
13
0
0
0
0
13
0
0
0
0
13
25
% L
% Met:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% M
% Asn:
0
0
0
13
13
13
0
0
13
0
13
0
0
0
0
% N
% Pro:
0
13
0
0
25
0
0
0
0
0
0
0
25
0
25
% P
% Gln:
13
0
0
0
13
13
0
13
0
0
13
25
0
0
0
% Q
% Arg:
0
25
0
0
0
13
0
0
0
25
0
13
0
0
0
% R
% Ser:
25
25
25
25
38
0
38
25
13
0
13
25
38
25
13
% S
% Thr:
0
0
0
13
0
0
13
13
0
0
25
0
0
13
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
13
13
0
0
0
13
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _